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At the joint microenvironment level, analyses of synovial fluid and cartilage tissue samples from OA patients, as well as studies in surgically induced such as the DMM model or chemically induced animal OA models, consistently observe clear iron metabolism abnormalities and significant iron accumulation locally in affected joints

( A ) Inflammation: During the various stages of wound healing, cytokines are involved in fluctuating concentrations to regulate the process

Entacapone also exhibited anti-ferroptosis activity to alleviate IRI-induced renal damage and pathological changes in mice and erastin- or RLS3-induced lipid peroxidation and iron accumulation

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis