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Vanharanta H, Sachs BL, Ohnmeiss DD, Spivey M, Guyer RD, Rashbaum RF, Hochschuler SH, Stith WJ, Mooney V: Pain Provocation and Disc Deterioration by Age: A CT/Discography Study in Low Back Pain Population

9,23 There is currently no consensus as to what is the best medication regimen to reduce the clinical severity, complications, and occurrence of sequelae

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This agent differs from earlier therapies that were designed to reduce myocardial loading or induce neurohumoral blockade