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Caspase-3 activation represents point of no return in apoptosis

Brady S, Cunningham S, Brubaker L, Falke C, James A, Kenton K, Low L, Markland A, Mcgwin G, Newman D, Norton J, Nuscis K, Rodriguez-Ponciano D, Rudser K, Smith A, Stapleton A, Sutcliffe S, Klusaritz H, Brubaker L, Fitzgerald C, Acevedo-Alvarez M, Hardacker C, Hebert-Beirne J, Griffith J, Kenton K, Simon M, Brown O, Geynisman-Tan J, Mueller M, Markland A, Vaughan C, Coyne-Beasley T, Burgio K, Lewis C, McGwin G, Williams B, Lukacz E, LaCoursiere D, Gahagan S, Nodora J, Low L, Miller J, Smith A, McGwin G, Rudser K, Brady S, Fok C, Harlow B, Rockwood T, Scal P, Newman D, Smith A, Berry A, Bilger A, Klusaritz H, Lipman T, Stapleton A, Wyman J, Sutcliffe S, James A, Lowder J, Meister M, Rickey L, Camenga D , Cunningham S, Brubaker L, Norton J

In a statement, Lange said that only 57% of patients reached the highest CagriSema dose, offering a pointer to one potential way to dial up the efficacy