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While effective in animal models, human data are limited to small case series [80]

Acknowledgements The research group from CNR-ISAFoM acknowledges that part of this project was funded under the National Recovery and Resilience Plan (PNRR), Mission 4 Component 2 Investment 1.3-Call for proposal No

Cho IH, Choi ES, Lim HG, Lee HH

Additionally, these studies also singled out the possibility that enhanced activity of glycolysis may have a bearing on exit from quiescence and HSC activation in at least some contexts [119], although the majority of literature has revealed that normal HSCs reside in a low-oxygen niche environment and their energy demands are highly dependent on the glycolytic pathway [122,123,124]

2 The chemosensitization effect of QUE in cancer chemotherapeutic The mechanisms of chemotherapeutic drugs are complex and include effects on DNA structure, inhibition of nucleic acid synthesis, DNA replication, and interference with mitotic tubulin (25): (1) The balance between drug absorption and excretion is disrupted, decreasing intracellular drug levels