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10.1016/S1474-4422(18)30295-3 Lancet Neurol

After 30 days on the 3 mg dose, increase the dose to 7 mg once daily

Moreover, inhibition of the C5a-C5aR axis by using the C5 antibody diminished cerebral lesion and improved motor functions in a rat model of stroke [55], and treatment with C5a receptor antagonistPMX53 significantly decreases ischemia-induced apoptosis of primary mouse cortical neurons subjected to oxygenglucose deprivation (an in vitro model of hypoxiaischemia) [56]

Measuring the GSH/GSSG ratio in pathological tissues and experimental models thereof in comparison to the results in controls is an excellent way to assess potential therapeutics efficacy in maintaining cellular redox potential