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Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage

doi: 165

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Improved Circulation : When coffee enters the colon, it triggers dilation of blood vessels, leading to increased circulation to the liver

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