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For example, in patients with eosinophilic asthma, the persistence of sputum eosinophilia despite high dose of corticosteroid identifies a subgroup of patients that despite Th2 inflammation are unresponsive to corticosteroids (17% of the totals in a recent study) (Berthon et al., 2017

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Tuberous sclerosis complex-1 deficiency attenuates diet-induced hepatic lipid accumulation

Other studies indicate that in sepsis, heightened mitochondrial fission leads to mitochondrial dysfunction, contributing to inflammation and tissue damage, particularly in organs like the lungs