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The maximum plasma concentrations (C(max)) of adducts for immediate release (IR) and extended release (ER) formulations were 0.108 (0.020) and 0.100 (0.028) nmol/mL serum, respectively, and were two orders of magnitude lower than the maximum APAP adduct levels previously reported in adults with acute liver failure secondary to APAP

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The appetite and energy systems that drive obesity are regulated by multiple overlapping hormonal pathways targeting just one of them has inherent limits

ME1 promotes basal-like breast cancer progression and associates with poor prognosis