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College of Liberal Arts & Sciences Nick Hays, Overland Park, Kansas

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This has not been demonstrated in clinical practice with oral glutathione at standard supplemental doses, but preclinical evidence warrants caution in cancer patients undergoing active treatment [2][5]

To avoid relying on statistical differences that do not involve a clear clinical impact, the concept of minimal clinically important differences (MCID) was employed (27) as is commonly used in PD drug trials and observational studies (2830)