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Constitutive activation of NF-B in myeloid cells, as a result of IB deletion using the LysM-Cre system, causes more severe CNS inflammation and clinical scores in myelin oligodendrocyte glycoprotein-induced EAE, 121 whereas myeloid cell-specific deletion of IKK inhibits EAE induction associated with impaired generation of inflammatory Th1 and Th17 cells

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[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Shah UA, Maclachlan KH, Derkach A, Salcedo M, Barnett K, Caple J, et al

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Later work has built on that finding, including a 2023 peer-reviewed review on MOTS-Cs role in metabolic disorders