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Hence, we can conclude that these actions may contribute to MTX-induced hepatotoxicity

All solvents were of UHPLC grade (Honeywell)

While the cells treated with Ru(II)-OH or NP2 in a 1% O 2 atmosphere were confluent and alive, the cell treated with NP4 had a strongly reduced cell population and a mixture of living and dead cells comparable to the treatment with these nanoparticles in a 21% O 2 atmosphere (Fig

Autophagy-independent functions of the autophagy machinery

The present study provides a novel pathway to produce polysulfide species Cys-SSH, GSSH and persulfurated proteins as well as H 2 S 2 and H 2 S 3 , and helps clarify the cellular signaling in which these persulfurated species are involved