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Introduction Oxidative stress is thought to contribute to the development of a wide range of diseases including neurodegenerative (Alzheimer, Parkinson, Amyotrophic Lateral Sclerosis), diabetes, cancer, rheumatoid arthritis, cardiovascular and liver diseases several of them are related with low levels of IGFs such as degenerative and aging disorders [1-8]

Abstract Sea buckthorn ( Hippophae rhamnoides L.) is a flowering shrub, and its berries have been utilized for decades as a raw ingredient in cuisines and herbal remedies

Moreover, additional compounds were developed to optimize the inhibition of Rab activity, such as triazole inhibitors, N-oxide derivatives of 3-PEHPC, and benzimidazole carboxyphosphonates [106]

single dose) can increase the concentration of 5-HIAA in the hypothalamus and striatum of mice [5]

Elastin gives it stretch