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2017;8(1):e02133-16

Recent improvements have increased its potential: Fast and efficient way for pre screening stable knockouts In species where stable transformation is feasible but time-consuming, VIGS provides a rapid means to identify interesting candidate genes before generating stable knockout lines

The apparent discrepancy regarding HIF-1 regulationwherein HBO preconditioning upregulates it, while post-injury HBO therapy may downregulate itcan be explained by the temporal context and the distinct oxygen dynamics involved

FDAs RUO guidance for IVD products warns that certain forms of applied interpretive information can conflict with research-use-only positioning in that regulatory context [16]