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Animal experiments indicated that formaldehyde, acetaldehyde, glyoxal and methylglyoxal have acute toxicity as well as and chronic toxicity, and furthermore, tube test also implied that these substances have genotoxicity, carcinogenicity, mutagenicity in different levels

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According to Shuja et al 11 in his study, plasma GSH levels in melasma patients decreased significantly compared to controls and are thought to be a risk factor in the severity of melasma