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In an in-vitro experiments, it was observed that miR-375 decreases the levels of the SIRT5 protein, leading to repressed autophagy and amplified apoptosis in HCC cells

doi:10.3390/pharmaceutics10030116 67

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A statin prescription was the primary exposure

The changes in the activities of glutamine synthase and xanthine oxidase led to the overproduction of ROS, which in turn caused oxidative DNA damage and activated the p53 signaling pathway to induce apoptosis (Wang et al., 2021a)