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2022;34(7):e2107054

The importance of mitochondrial pyruvate carrier in cancer cell metabolism and tumorigenesis

The likely-resulting endotoxemia from intestinal barrier dysfunction stimulates toll-like receptor 4 (TLR4) in Kupffer cells to produce NADPH-oxidase (NOX)-dependent ROS [213] and activate HSCs, leading to fibrosis [144, 219]

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