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Interestingly, the first of the two cited articles stated that the study's means of determining if the dogs had enlarged hearts was to carefully examine x-rays of the dogs' hearts - a previously routine veterinary procedure which this October 2017 study's cardiologists seem intent to avoid

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Non-invasive approaches include intranasal drug administration (IN) and use of brain targeting nanoparticle drug delivery systems

Recognizing these axisrelated mechanisms deepens understanding of PD etiology and identifies potential peripheral biomarkers and novel therapeutic targets linked to these systemic pathways