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4.1.3 Ferroptosis suppressor protein 1(FSP1) -coenzyme Q10 (CoQ10)-NADPH pathway The FSP1-CoQ10-NAD(P)H pathway is crucial in ferroptosis prevention, alongside the GPX4 pathway, the main defense mechanism

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Further, the interaction between CHAC1 and the ATF4-CHOP pathway elucidates a feedback loop where oxidative stress enhances ER stress, which in turn aggravates oxidative stress through CHAC1-mediated GSH depletion

This structural and functional complexity hampers the precise characterization of their spatiotemporal dynamics in vivo and complicates the establishment of standardized dosing regimens and therapeutic windows

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