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Several other mechanisms could contribute to therapy resistance, including a paradoxical increase in mitochondrial ROS production during hypoxia through a HIF-1 regulation loop (Murphy, 2009)

Due to the rapid proliferation of GBM, the TME is suppressed by factors such as acidity and hypoxia, rendering immunotherapy ineffective [95, 96]

Flaxseeds have been shown to tolerate temperatures up to 350F/178C for two hours without undergoing structural change of their ALA

Inflammation Bowel Dis (2010) 16(12):201221

Results revealed that PBMT with lower intensity (0.03 J/cm 2 ) increased succinate dehydrogenase (SDH) activity and glutathione (GSH)/oxidized glutathione (GSSG) ratio in hyperthermia-induced azoospermia mice