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Immune-related adverse events (irAEs) are frequent during ICI therapy and have been associated with improved outcomes, while baseline inflammatory markerssuch as C-Reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR)often predict poor prognosis

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doi:10.1016/j.jtemb.2020.126541 Opstad TB, Alexander J, Aaseth J, Larsson A, Seljeflot I, Alehagen U

They send instructions that regulate many natural processes