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Renal carnitine loss may also affect the morphology and function of red blood cells and reduce the oxygen carrying and releasing capacity of red blood cells, thereby reducing tissue oxygen supply (including the kidney), and tissue hypoxia activates hypoxia-inducible factor 1 (HIF-1), which in turn reduces OCTN2 expression through the HIF-1-PPAR signaling pathway

Zhang FP, Malinen M, Mehmood A, Lehtiniemi T, Jskelinen T, Niskanen EA, Korhonen H, Laiho A, Elo LL, Ohlsson C, Kotaja N, Poutanen M, Sipil P, Palvimo JJ

doi:10.1002/ardp.19292670410

When it is prepared into colorectal cancer-targeted calcium phosphate nanoparticles, it is found that it has almost no obvious effect on the morphology of red blood cells, and there is no obvious generation of red blood cell fragments, thus reducing the hemolytic toxicity of paris saponin VII [142]

96 OriC.DalsassoM.FreoU