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Blocking the transmission of the HGF/c-MET pathway in CAFs has been demonstrated to impede the movement of CRC cells driven by RAB31 expression, highlighting the role of CAFs in enhancing paracrine HGF release and stimulating the HGF/c-MET pathway, which in turn propels tumor growth [48]

Xingi E, Koutsoudaki PN, Thanou I, Phan MS, Margariti M, Scheller A, et al

Representative distribution/elimination curve for Dihexa

Define the Project Record why BPC-157 is required and how it relates to an approved scientific programme

As a significant genetic risk factor for sporadic AD, the Apolipoprotein E (APOE4) allele demonstrates a reduced affinity for LRP1 in pericytes