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Allowing the injectable solution to reach room temperature before injection decreases the temperature gradient between the medication and your skin, reducing thermal irritation signals

While clinical studies primarily evaluate the safety and efficacy of the medication, Human Factors (HF) studies assess how safely and effectively users interact with the device

8 Longer exposure times may also be related to an indwelling, intra-articular catheter which is sometimes left in the joint for a period to provide pain-relief post-operatively

Lack of serum B12 levels or methylmalonic acid/homocysteine measurements: The diagnosis of B12 deficiency, although clinically justified, would have been more robust with documented low B12 levels and elevated methylmalonic acid/homocysteine