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[,,,] Mechanistically, Them2 limits the rates of fatty acid oxidation in the skeletal muscle, thus, decreases the demand by the skeletal muscle for fatty acids in the form of secreted hepatic VLDL TG

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Preclinical studies show neuroprotective effects in models of traumatic brain injury, spinal cord compression, and peripheral nerve transection

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They can also cross the BBB and activate TLRs in the brain (35)

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