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PLoS One 9:e108024

ROS accumulation leads to metabolic abnormalities in RA-FLSs, with decreased mitochondrial oxidative phosphorylation and ATP reserve capacity but increased glycolytic activity in RA-FLSs, promoting RA synovial inflammation (106)

& Akagi, Y

The significance of epithelial cells is further substantiated by in vitro studies, which shows that various types of injuries can trigger kidney proximal tubular epithelial cells to exhibit characteristics of senescence (Jin et al., 2019)