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doi: 10.1016/j.biopha.2023.115252 247 ZhangYLiHChenYLiCYeHQiuJet al

By promoting the efficient use of fat as fuel, L-Carnitine supports energy levels, endurance, and overall metabolic function

Growth hormone is counter-regulatory to insulin, meaning it opposes insulins actions and raises blood glucose levels

27,28 Though omega-3 PUFAs dont appear to have any alarming short-term side effects, caution is advised when recommending PUFA supplementation over extended periods due to the possibility of increased adverse effects of omega-3 supplementation, like nausea, fishy belching, loose stools, and prolonged bleeding time particularly due to higher dosage of administration or due to oxidation products or added vitamin E

Ultimately, combining redox-modulating strategies with EV-based or nanotherapeutic platforms, guided by patient-specific profiling, may represent a rational path toward extending ovarian healthspan and improving reproductive outcomes