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However, while superior organisms, like humans, cannot synthesize carotenoids, they rely on dietary intake to benefit from their antioxidant properties and maintain normal physiological functions [10]

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Furthermore, a crosstalk between insulin-induced ERK and epidermal growth factor (EGF) favored tumorigenesis by triggering the expression of anti-tumor immunity inhibitor programmed death-ligand 1 (PD-L1) in a cancer common in individuals with insulin resistance, pancreatic ductal adenocarcinoma (78)

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