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Mechanistically, diabetes and HIV-1 collaboratively increase the expression of miR-34a in the glomeruli, leading to the reduction in SIRT1 expression

More specifically, the prominent role of Nrf2 pathway in oxidative stress handling throughout life is further emphasized by the fact that the inhibition of this pathway by progerin has been incriminated in the premature aging occurring during progeria disease (Silva-Palacios et al., 2016)