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THE RELEVANCE OF NONSTANDARDISED IN VITRO NASAL CAST MODELS IN PRODUCT DEVELOPMENT Lucas Silva1 , Nathalie Hauchard2, Nuria Manzano1 & Gonalo Farias2 1Nanopharm Ltd, Franklin House, Grange Road, Cwmbran, NP44 3WY, UK 2Aptar Pharma, Route des Falaises, Le Vaudreuil, 27100, France Summary: More realistic in vitro tools are being explored to facilitate product development by providing a better link between in vitro studies and in vivo outcomes

We included in the final review 17 papers, some of them measuring multiple environmental toxicants evaluated in unique study populations [19,29,30] (Figure 2)

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Pereira da Silva L, Miguel Neves B, Moura L, Cruz MT, Carvalho E (2014) Neurotensin decreases the proinflammatory status of human skin fibroblasts and increases epidermal growth factor expression