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44 MawuenyegaKGForstCVDobosKMBelisleJTChenJBradburyEMet al

n = 6 animals analyzed in 2 independent experiments

RNF8 C406S S-tag was subsequently generated using site-directed mutagenesis

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Remarkably, the varied modulators of ion balance within lysosomes have themselves been recently implicated as causative for major neurological diseases (Fig