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The resulting HSA-Mn 3 O 4 and HSA-TI are then cross-linked via ROS-cleavable thioketal linkers and covalently immobilized onto platelet, forming the platelet-nano assemblies 55

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105 Activation of the RhoA/ROCK pathway impairs NO bioavailability through inhibition of eNOS mRNA stability, eNOS posphorylation at Ser 1177 and the Akt/PI3K pathway and enhancement of eNOS phosphorylation at Thr495