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Nrf2 can repress NOS-2 activity [60], yet higher Nrf2 levels were not sufficient to keep NOS-2 levels in check in the prevention experiment

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For instance, in rabbit reticulocyte lysates (RRL), 100% m 6 A repressed translation, whereas in HEK293 and primary mouse dendritic cells, incorporating 5% m 6 A did not lead to any significant change in target protein expression compared to unmodified mRNA [108]