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Am Surg Assoc:100-101, 2002

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Melse-Boonstra, A

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Bidirectional regulatory contradiction: METTL3 simultaneously mediates the m 6 A modification of the 5UTR of dCK mRNA, promotes nuclear export and translation through YTHDC1, and enhances gemcitabine activation, while FTO demethylates dCK, reducing its stability, forming a balanced antagonism that promotes drug resistance/sensitization