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However, lactate can simultaneously upregulate acetylation to promote gene transcription, whereas Nala exclusively modulates lactylation 40

10.1021/acs.molpharmaceut.5c00297 127 RieseP.SakthivelP.TrittelS.GuzmnC

20 Similarly, for patients with HACE, low-flow oxygen (24 L/min) is recommended to alleviate symptoms, albeit with limited research

Indeed, the UPR has been regarded as an important pharmacological target in the development of therapeutic strategies for immune-mediated pathology (11)