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Pharmacol Res Perspect 3:110

123,124,125 To attenuate side effects and broaden the therapeutic window, modulators that can abolish -arrestin activity while maintaining relatively intact G-protein signaling are of intense pharmaceutical interest

& Guan, L

If the cut-off for deficiency is set higher, you diagnose more people who have deficiency, but you also end up treating more people who dont have a deficiency

However, there remains the question whether established seno-antigens are sufficiently representative of the heterogeneous senescent cell population, and to what extent they are able to ameliorate senescent cell burden in vivo