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Nature 448 , 457460 (2007)

In addition, spinal exposure to recombinant caspase-6 not only facilitates microgliosis and microglial activation to result in TNF- secretion, but also increases glutamate release from primary afferent terminals to enhance excitatory postsynaptic currents ( Other Caspases In addition, recent report recapitulates the elevated concentration of caspase-11, NOD-like receptor C4 (NLRC4), ASC, and IL-1 in the brain and spinal cord of mice with lipopolysaccharide (LPS)-induced inflammatory heat hyperalgesia ( Caspases and Cancer Pain Caspase-1 Cancer pain is also an important category of chronic pain and have the distinctive characteristic of both neuropathic pain and inflammatory pain processing (Wang K