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NPI-001s advantages as a therapy, based on preclinical models, include: Ability to cross blood-brain 33 and blood-retinal barriers 2 Greater cell permeability than NAC 34 Approximately 3-fold more effective than oral NAC 32 , 31 NPI-001 oral tablets have been evaluated in a Phase 1/2 clinical trial (NCT04355689) in patients with RP associated with USH, demonstrating clinical proof of concept

This suggests that these metabolites reflect metabolic integrity of cells (see SA8 for further discussion)

Autonomic nerves, which control both voluntary and involuntary bodily functions such as blood pressure, may also be affected

& Cordeiro, M

Aloe vera vs triamcinolone acetonide : In a comparative trial by (Choonhakarn et al