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It also raised levels of Th1-associated cytokines such as IFN-, IL-2, and TNF- and enhanced the growth of the CD8 + dendritic cell (DC), which exhibited higher expression of CD86 and CD80 molecules [101]

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53 Furthermore, the role of NOX4 in apoptosome formation and its ability to influence caspase -3 and Bcl2 expression, as well as cause leakage of cytochrome c from the mitochondria via ROS production, make NOX4 an interesting focus of future research to treat liver ailments

Anticancer Res 25:45274533 Siegel RL, Miller KD, Fuchs HE, Jemal A (2021) Cancer statistics

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