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So on the narrow question does it stop working after N weeks, the honest answer is: no published evidence says it does, and the mechanism actually argues against it

Discussion All of the grassland plants from the on-site records of charred macro-remains which are typical for fallow land decrease clearly after the Hallstatt and La Tne periods in the Iron Age

Astrocytes in AD model animals demonstrated up-regulated expression of genes (CPS1, OCT, ASL, ARG1, and ODC1) and metabolites (aspartate, ammonia, urea, putrescine, and GABA) of the urea cycle