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Toca 511 plus 5-fluorocytosine in combination with lomustine shows chemotoxic and immunotherapeutic activity with no additive toxicity in rodent glioblastoma models

Histone deacetylase inhibitors, like 4-phenylbutyrate and sodium butyrate, can induce histone acetylation but show limited effects when used alone (218)

When a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off)

doi: 55

Metals, including lead, mercury, aluminum and arsenic, can cause short- and long-term health consequences since they impact functions of the central nervous, cardiovascular, immune and skeletal systems