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This keeps the two actives in separate applications entirely and is often the best-tolerated structure

Trials typically incorporate biomarker endpoints such as ER/ER ratios, aromatase activity, plasma isoflavone or polyphenol concentrations, immune cell phenotyping, cytokine panels, oxidative stress markers and microbiome profile which are used to provide mechanistic read-outs of supplement activity and to inform patient stratification approaches (231)

For example, UCHL5 accelerates growth of endometrial cancer by activating the WNT-catenin beta 1 (CTNNB1) pathway (Liu et al., 2020)

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