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Ferroptosis: past, present and future

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727729 CFE also enables the production of enzymes that may be otherwise toxic to life, due to the in vitro nature of the method (Section 3.1.6)

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Historically, transcription factors like C/EBP have posed therapeutic challenges due to their absence of enzymatic activity and well-defined small-molecule binding sites, rendering them difficult to target directly with traditional drugs (Hattori et al., 2003)

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