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Indeed, a recent clinical study demonstrated that giving oral propionate (a microbial metabolite) to MS patients increased their peripheral Treg counts and was associated with a lower annual relapse rate over the ensuing 3 years [188]

51 For patients who have no other treatment options, this may allow them to continue treatment, Further reports into this topic are expected

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These tools have only recently become widely accessible, explaining why the full scope of bioregulator peptide mechanisms remained unclear for decades after their initial discovery