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Elevated BHB levels suppressed AKT activation in cardiomyocytes, while BDH1 overexpression effectively restored AKT/GSK3 pathway activity and ameliorated BHB-induced mitochondrial dysfunction and cardiomyocytes apoptosis

(2) NMN co-treatment was conducted by adding 90 L of 250/500 M NMN for four hours prior to chemotherapy treatment, and this was performed by adding 20 L from a series of descending drug concentrations to the cell culture plate with either bleomycin, cisplatin, doxorubicin, etoposide, gemcitabine, methotrexate, paclitaxel or vincristine

R., & Nandagopal, A

Thus, PHGDH may represent a novel therapeutic target for reversing recurrence and resistance to tamoxifen in ER + breast cancer (129)

It supports healthy ovulation and sperm production, enhancing overall fertility