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This lack of response to GW7647 has been previously attributed to the downregulation of Ppara in the liver 6h after CLP ( Liver-i-KO mice, both in sham and CLP, compared to Hnf4a flfl mice, but not in Hnf4a flfl mice 8h after CLP ( Figure 2F ), but was decreased at later stages of sepsis, between 24h and 96h after CLP ( Figure 2G )

112,113,114,115,116 This inhibition is relieved when glycolytic flux is elevated

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The efficacy of adjunctive N-acetylcysteine in major depressive disorder: a double-blind, randomized, placebo-controlled trial