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Key benefits for perimenopausal women: May restore deep, slow-wave sleep stages that are commonly fragmented during hormonal transition Modulates cortisol and stress-hormone levels, addressing the elevated HPA axis activation linked to estrogen decline Animal research documents DSIP stimulates growth hormone (GH) release via hypothalamic and pituitary actions, and separately stimulates LH release via a hypothalamic site of action in estrogen-primed subjects Administration method: Subcutaneous injection, typically administered 1-3 hours before bedtime

They can cause sores in the nose, ulceration of skin, and nail infections

Finally, amino acid metabolic imbalance exacerbates immunosuppression

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2012;130(2):427-434.e6