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Here are seven reasons why you may have a B12 deficiency and could benefit from a B12 supplement/injection: You are older as it becomes harder for the body to absorb B12 as we get older You drink heavily as alcohol can hinder the bodys ability to absorb B12 You had weight loss surgery or another operation that removed part of your stomach You are a vegetarian and dont eat enough eggs or dairy products to meet your vitamin B12 needs You have a Crohns disease , celiac disease or any condition that affects your small intestines You have an immune system disorder such as Graves disease or lupus You take certain heartburn medications such as Neium and Prilosec

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Predictive biomarkers such as baseline NAb titers and ISG signatures will become more widely used to anticipate treatment responses and therapeutic efficacy ( + tumor-infiltrating lymphocytes (TILs) and PD-L1 expression, as well as the rate of circulating tumor DNA (ctDNA) clearancewill facilitate real-time efficacy assessment and dose adjustment ( Table 8 Emerging biomarkers for Oncolytic Virus (OV) therapy in malignant melanoma