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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

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Carotenoids (i.e., lipid-soluble phytochemical) exert similar antioxidative properties [86] but are also discussed to decrease lipid accumulation, insulin resistance, oxidative stress, and inflammation in the liver [87]