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One of the major drawbacks is their large molecular mass of about 150 kDa, responsible for slow kinetics and limited tumor penetration with only approximately 20% of the administered dose reaching the tumor site [85]

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Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism