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low plant, high animal protein intake (high-risk) groups Comparisons of the metabolic profiles between the low-risk and high-risk dietary protein intake groups are shown in Supplementary Table 3

There are significant differences in response to ICB therapy among CRC patients, with studies showing that individuals exhibiting deficient mismatch repair (dMMR) or high levels of microsatellite instability (MSI-H) tend to respond more favorably to ICB treatment, while the efficacy is limited for patients with microsatellite stability (MSS) (Jin and Sinicrope, 2022)

It is unclear whether malate, Cit, or both, are responsible for the effects observed in studies on CitMal supplementation

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